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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Parthenolide, Epirubicin
Phytochemical Name Parthenolide (PubChem CID: 7251185 )
Anticancer drug Name Epirubicin (PubChem CID: 41867 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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The theory of cold and heat
Drug Name Epirubicin
Adverse Reactions Nausea, vomiting, diarrhoea, loss of appetite, inhibition of bone marrow haematopoiesis. This was inferred cold nature anticancer drug.
Recommendations Hot: Pinellia ternata
Reference ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.　　ref_link
Combination Pair ID: 173
Ref_1
Pair Name Parthenolide, Epirubicin
Disease Info [ICD-11: 2C60] Breast cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
Up-regulation Expression CASP3 hsa836
In Vitro Model MDA-MB-468 Breast adenocarcinoma Homo sapiens (Human) CVCL_0419
Result According to lack of cytotoxicity of Parthenolide on normal cells that lead to reduction of drug side effects, it could be suggested as an adjuvant therapy with Epirubicin after complementary research on animal model and clinical trial.
03. Reference
No. Title Href
1 Anticancer and apoptotic activities of parthenolide in combination with epirubicin in mda-mb-468 breast cancer cells. Mol Biol Rep. 2020 Aug;47(8):5807-5815. doi: 10.1007/s11033-020-05649-3. Click
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